World-first agreement between Novartis and NHS for cholesterol drug

World-first agreement between Novartis and NHS for cholesterol drug

Novartis has reached a commercial agreement with the NHS in England, enabling broad and rapid access to the cholesterol-lowering medicine Leqvio®▼(inclisiran). The collaboration pioneers a first-of-its-kind population health management approach to address elevated LDL cholesterol (LDL-C) in eligible patients with ASCVD across England[1].

Over three years, approximately 300,000 patients at high risk of a second cardiovascular event are expected to be treated with inclisiran, a small interfering RNA therapy administered as a 6-monthly maintenance dose, in the community setting.

The collaboration follows the positive final recommendation from the National Institute for Health and Care Excellence (NICE) for use of inclisiran in primary care. Novartis will work with the NHS Accelerated Access Collaborative and the Academic Health Science Network (with the support of NHS Digital) to help them proactively identify, treat and monitor eligible individuals with ASCVD who have experienced a cardiovascular event, such as a heart attack or stroke, and have high cholesterol despite treatment with maximal tolerated statins.

Professor Kausik Ray, MD, Professor of Public Health at Imperial College London and Honorary Consultant Cardiologist at the Imperial College NHS Trust said: “This population health management approach is potentially game-changing, seeking to improve a nation’s health by proactively identifying individuals ‘at highest risk’ and introducing effective solutions that will improve their future health state. This represents a significant advance in patient care through effective lipid management. As a clinician, I see many patients where their cholesterol levels are insufficiently controlled for their level of risk, often despite optimal use of available therapies, puttting them at increased risk of a heart attack or stroke. Having faster and broader access to a medicine like inclisiran, which offers the combination of a convenient twice-a-year maintenance dosing schedule, as well as the ability to be used in primary care – where most patients are cared for – and provide sustained reductions in LDL-C is a hugely positive milestone in patient care.”

Vas Narasimhan, Novartis CEO said: “Cardiovascular disease has long been the number one cause of human mortality, and this intractable health issue requires a reimagining of how we treat heart health. This pioneering collaboration with the NHS in England has the potential to spur a step-change improvement in cardiovascular health across the UK, and it demonstrates Novartis’ commitment to working with healthcare systems around the world to improve patient outcomes by co-creating novel access solutions for innovative medicines.”

Reference

[1] National Institute for Health and Care Excellence. Inclisiran for treating primary hypercholesterolaemia or mixed dyslipidaemia [ID1647] https://www.nice.org.uk/guidance/indevelopment/gid-ta10703.