The announcement comes just six weeks after Pfizer unveiled the closure of its biggest European R&D site in Kent.
The Swiss company said it is consulting with staff on its plans, but that the restructuring is expected to result in the loss of around 500 positions from the 950 staff on the campus.
The Government recently pledged the largest ever sum of money to support and fund healthcare R&D in the UK in the hope of encouraging pharma research back to the country.
Novartis is seeking to streamline its business globally to prepare for the impact of patent expiries on some of its best-selling medicines.
Despite these cut backs, the company has committed to providing the equivalent of over USD 3 million in immediate relief aid to the victims of the recent earthquake in Japan.