Novartis reaffirms its commitment to the fight against liver fluke

expanding access to medicines

Novartis reaffirms its commitment to the fight against liver fluke (fascioliasis), signing a renewed memorandum of understanding with the World Health Organization (WHO) to extend its drug donation for Egaten® (triclabendazole) until 2022. Egaten is currently the only treatment for fascioliasis recommended by the WHO and is on the WHO Model List of Essential Medicines.

This new four-year commitment includes the donation of 600,000 tablets of Egaten annually, expected to reach 300,000 patients per year. Since the start of the donation program in 2005, Novartis has donated approximately 4 million tablets of Egaten, valued at USD 41 million, helping to treat around 2 million people with fascioliasis in more than 30 countries worldwide.

Fascioliasis, commonly known as liver fluke infestation, is a neglected tropical disease (NTD) that currently affects an estimated 2.4 million people worldwide. It is caused by two species of parasitic flatworms or trematodes that mainly affect the liver (Fasciola hepatica or Fasciola gigantica). Both species can infect humans following ingestion of larvae in contaminated water or food (mainly raw or undercooked vegetation). No continent is free from fascioliasis; human cases have been reported from more than 70 countries worldwide.

Left untreated, fascioliasis can result in considerable pain and discomfort, leading to poor quality of life and loss of productivity. The acute phase of the disease is manifested with fever, abdominal pain, nausea, diarrhea and eosinophilia. The disease later progresses to a latent phase with less symptoms and ultimately into a chronic or obstructive phase.

Egaten is a single-dose treatment for fascioliasis caused by Fasciola hepatica or Fasciola gigantica in patients 6 years of age or older. Novartis originally developed triclabendazole to treat fascioliasis in domestic livestock, and subsequently developed it for human use in partnership with the WHO.

Antonio Montresor, M.D., Medical Officer, WHO Department of Control of Neglected Tropical Diseases said, “This donation will help increase access to treatment in many countries, particularly in communities where cases are clustered and among children of school age who have both the highest prevalence and intensity of infection.”

Patrice Matchaba, M.D., Group Head of Global Health and Corporate Responsibility said, “Novartis looks forward to its continued partnership with the WHO to reduce the burden of fascioliasis around the world through access to effective treatment. The extension of our donation through 2022 is a testament to our company’s long-term commitment to reimagine the fight against neglected tropical diseases.”