NICE to recommend Roche’s revolutionary cancer treatment

Image of a contract and pen to show NICE to recommend Roche's revolutionary cancer treatment

Entrectinib, Roche’s Rozlytrek® ▼, a revolutionary treatment for a range of cancers, is the second histology independent drug to be recommended by NICE for use on the Cancer Drugs Fund (CDF).

As a histology independent treatment, entrectinib targets all solid tumours that have a certain genetic mutation (a neurotrophic tyrosine receptor kinase (NTRK) gene fusion), regardless of where the cancer originated in the body.

This is particularly beneficial to patients with some rare types of cancer where the treatments are currently limited.

The final draft decision is set to benefit adults and children 12 years and older, with advanced NTRK fusion-positive solid tumours, who have no satisfactory treatment options. Eligible patients will have access to entrectinib through the CDF once the marketing authorisation has been granted.

Karen Lightning-Jones, Head of Personalised Healthcare and Strategic Partnerships at Roche Products Limited said: “People across England will be among the first in Europe to benefit from a new generation of medicine that targets tumours based on their genetic make-up, rather than where they are in the body.

“We are proud to have worked in partnership with NHSE, NICE and the Accelerated Access Collaborative, to fast-track access. We look forward to the English Genomic Medicine Service being able to operate at full capacity and help identify those patients who may benefit from entrectinib. Our commitment is to ensure that people in the UK live longer and healthier lives, and today’s news shows how we are advancing science to achieve this.”

Meindert Boysen, Deputy Chief Executive and Director of the Centre for Health Technology Evaluation at NICE, said:“Today’s decision is another positive step forward for cancer care driven by genomics. Treatments like entrectinib, have the potential to revolutionise how we treat cancers by targeting a genetic mutation that activates tumour growth irrespective of the solid tumour’s location.

“While the evidence suggests that solid tumours with NTRK gene fusions shrink in response to entrectinib, further trial data is needed. We are therefore pleased that, because of the joint working between NICE, NHS England and NHS Improvement and the company, adults and children 12 years and older will be able to access entrectinib on the CDF while more data is collected to address any clinical uncertainties.”

Professor Peter Johnson, NHS Clinical Director for Cancer said: “As well as helping cancer patients to continue to get essential care during the coronavirus pandemic, the NHS has been working to bring new treatments onto the frontline of patient care.

“This is the latest deal that the NHS has struck, working together with Roche, to help hundreds of cancer patients every year who will now be able to have this important molecular targeted treatment.”

Between 600 to 700 people have solid tumours with NTRK gene fusions. A proportion of these people, who have no satisfactory treatment options, will be eligible for treatment within the first year that it is available on the CDF.

Earlier this year, NICE also recommended histology independent treatment, larotrectinib (Vitrakvi, Bayer), for a similar patient group on the CDF. Larotrectinib was the first histology-independent treatment to be made available for NHS patients in England through the Cancer Drugs Fund.