NICE recommends ADCETRIS▼ (brentuximab vedotin), in combination with chemotherapy, as frontline treatment for a rare type of lymphoma

Image of two business people shaking hands in front of a contract to show NICE recommends ADCETRIS (brentuximab vedotin), in combination with chemotherapy, as frontline treatment for a rare type of lymphoma

Takeda UK has announced that the National Institute for Health and Care Excellence (NICE) has recommended ADCETRIS (brentuximab vedotin) with cyclophosphamide, doxorubicin and prednisone (CHP), within its marketing authorisation, as a treatment option for untreated systemic anaplastic large cell lymphoma (sALCL) in adults,1 within a final appraisal document (FAD).7

sALCL is a rare and clinically aggressive disease.2,3,4 It can be difficult to diagnose, meaning many cases are not identified until Stage III or IV.2,8 The frontline treatment for newly diagnosed sALCL patients has typically been multi-agent chemotherapy, such as CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone),2,8,9 which is generally associated with poor outcomes, with many patients failing to achieve long-term survival.4 Clinical practice guidelines also recommend inclusion in clinical trial as a frontline option for sALCL, further highlighting the need for novel therapies.8

The recommendation from NICE, which reflects the marketing authorisation extension from the European Commission, is based on the results of the Phase 3 ECHELON-2 study evaluating brentuximab vedotin in combination with CHP, compared to the current standard CHOP chemotherapy, in patients with CD30+ PTCL. sALCL is a type of PTCL and 70% of patients included in the ECHELON-2 study had sALCL.5

Takeda sought regulatory approval of brentuximab vedotin in combination with CHP in previously untreated patients with CD30+ PTCL. However, the level of evidence in the sALCL population was considered to be greater compared to the other subtypes enrolled in the ECHELON-2 trial, therefore the European Commission granted the sALCL indication only.

In the sALCL patient population, brentuximab vedotin plus CHP demonstrated superior progression-free survival (PFS) and overall survival (OS), versus CHOP, as assessed by Blinded Independent Central Review (BICR) (Hazard ratio [HR]=0.59; p-value=0.0031 and HR=0.54; p=0.0096, respectively). This corresponds to a 41% reduction in the risk of a progression event and a 46% reduction in the risk of death.1,5

ECHELON-2 also found that brentuximab vedotin in combination with CHP demonstrated:

  • A higher rate of objective response vs CHOP (88% vs. 71%, nominal p<0.0001)1
  • A higher rate of complete response vs CHOP (71% vs 53%, nominal p=0.0004) 1
  • A comparable safety profile to CHOP, with a similar incidence of peripheral neuropathy (52% vs. 55%) and febrile neutropenia (18% vs. 15%)1,5

Tim Illidge, Professor of Targeted Therapy and Oncology at The Christie NHS Foundation Trust said: “Progress in improving outcomes in the frontline treatment of sALCL has been lacking for decades and there has been an urgent medical need to improve survival. Historically, there has been a significant risk of rapid relapse and no effective re-treatment options. The data seen in this large Phase 3 randomised trial with brentuximab vedotin plus CHP in the untreated sALCL patient population is practice changing and has the potential to significantly improve the chance of survival for patients. This is the first large randomised study in T cell lymphoma to show real clinical benefits, providing new hope for patients fighting this aggressive disease.”

Brentuximab vedotin is already available as a monotherapy for adult patients with relapsed/refractory sALCL in England, Wales and Northern Ireland after failure of at least one chemotherapy agent.1,10,11

Stephen Scowcroft, Director of Operations and External Affairs, Lymphoma Action said: “Being diagnosed with a rare type of lymphoma, like systemic anaplastic large cell lymphoma, can have a significant impact on the quality of life of patients and their family or friends. Not only can the disease and the current treatment options have a physical impact, but the psychological impact of being diagnosed with a rare cancer, with potentially poor outcomes, can be devastating. That is why we are really pleased that newly diagnosed patients can now have access to an effective treatment, that can improve their quality of life and outcomes.”

Jon Neal, Managing Director, Takeda UK & Ireland said: “Brentuximab vedotin is a medicine that continues to innovate and transform the treatment paradigm for patients with rare types of lymphoma. We are committed to working in partnership with the clinical and patient community, and NICE and NHS England, to ensure as many eligible patients can benefit from access to this medicine as possible. We are therefore delighted that NICE recognised the significant benefit that brentuximab vedotin can bring to patients with this aggressive disease and we hope this rapidly becomes the new standard of care.”

REFERENCES

  1. Medicines.org.uk. 2020. Adcetris 50 mg powder for concentrate for solution for infusion (SmPC) – (Emc). Available at www.medicines.org.uk/emc/product/2859/smpc. Accessed June 2020
  2. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®). T-cell Lymphomas. Version 1.2020. Available at www.nccn.org/professionals/physician_gls/pdf/t-cell.pdf. Accessed June 2020
  3. Foss FM, et al. Blood 2011;117:6756–6767
  4. Vose JM, et al. J Clin Oncol 2008;26:4124–4130
  5. Horwitz S, et al. Lancet 2019;19;393:229–240
  6. Takeda Data on File UK/DF/2005/0003
  7. National Institute for Health and Care Excellence. Final appraisal document – Brentuximab vedotin in combination for untreated systemic anaplastic large cell lymphoma. ID1586. June 2020. Available at: https://www.nice.org.uk/guidance/indevelopment/gid-ta10514 Last accessed: July 2020
  8. Dearden CE, et al. Br J Haematol 2011;153:451–485
  9. d’Amore F, et al. Ann Oncol 2015;26:v108–v115
  10. National Institute for Health and Care Excellence. Brentuximab vedotin for treating relapsed or refractory systemic anaplastic large cell lymphoma [TA478]. Available at www.nice.org.uk/guidance/ta478. Accessed June 2020
  11. Health Service Executive. NCCP Chemotherapy Regimen Brentuximab vedotin Monotherapy. Available at www.hse.ie/eng/services/list/5/cancer/profinfo/chemoprotocols/lymphoma-myeloma/234-brentuximab-vedotin-monotherapy-regimen.pdf. Accessed June 2020