Data indicates rise in opioid use for migraine treatment

Man standing at flipboard with graphs and charts on it to show Fewer than half of US clinical trials comply with law on reporting results

Eli Lilly and Company has announced the upcoming presentation of data indicating rising rates of opioid use for the treatment of migraine based on results from the OVERCOME (Observational Survey of the Epidemiology, Treatment and Care of Migraine) study.

These findings will be presented at the 61st Annual Scientific Meeting of the American Headache Society taking place in Philadelphia.

Despite opioids typically being reserved for limited or highly specific uses and not a treatment of choice for migraine, results from OVERCOME demonstrated that a high number of people are using opioids to treat their migraine.

These findings suggest that the real-world treatment of migraine is falling short of current scientific understanding of how to optimally treat this serious and disabling neurologic disease.

The seminal 2009 American Migraine Prevalence and Prevention Study demonstrated that 16 percent of people with migraine were currently using opioids at the time of the study.

Data from OVERCOME collected in 2018 showed 19% of people with migraine were currently using opioids specifically to treat migraine. This could represent a potential increase of tens of thousands of adults using opioids for migraine compared to the previous decade.

Furthermore, among OVERCOME participants who reported four or more migraine headaches per month, nearly 1 in 4 were currently using opioids (23.9%) and more than 50% of people in this group reported using opioids at some point to treat their migraine.

Dr Sait Ashina, Department of Neurology and Department of Anesthesia, Critical Care and Pain Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, said: “The data from OVERCOME showed that, overall, opioids are being used in place of medicines that are approved and indicated to treat migraine, particularly among those who experience migraine headaches more frequently.

“These data show that, despite the known potential risks of using opioids for migraine, far too many continue to do so. Against the backdrop of the U.S. opioid epidemic, it’s concerning that many people may be using these drugs in place of therapies indicated for migraine.”

Dr Eric Pearlman, Ph.D, senior medical director, U.S. neuroscience, Eli Lilly and Company, said: “Considering the social, economic and health consequences of both migraine and opioid use, now is the time to close the treatment gap that has existed for too long. It’s vital those living with this chronic, neurological disease are aware of and being counseled on appropriate treatment options for their migraine.”