Diagnosing Lyme disease if bull’s eye rash is present – NICE quality standard

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Doctors should be diagnosing Lyme disease if bull’s eye rash is present, says NICE as it launches its Lyme disease NICE quality standard consultation.

The National Institute for Health and Care Excellence says that people showing erythema migrans, the characteristic skin rash associated with Lyme disease, can be diagnosed with the disease using clinical assessment alone, eliminating the need for blood tests.

Lyme disease is an infection transmitted by the bite of a tick. Prompt diagnosis and early treatment helps reduce the risk of further symptoms developing.

Laboratory tests check for antibodies in the blood however, Lyme disease antibodies may appear six to eight weeks after a person has been bitten by a tick. Early laboratory tests may not detect the disease and could slow diagnosis.

Erythema migrans is a skin rash associated specifically with Lyme disease and is present in approximately two-thirds of all cases. It is a red rash that usually appears one to four weeks following a tick bite and can have a bull’s-eye like appearance. When there is no rash, lab tests can be used to guide a Lyme disease diagnosis.

In the absence of erythema migrans and presentation of other symptoms, an initial ELISA laboratory test can be used. If this initial test is carried out too early for antibodies to have developed, people may have a negative result and the ELISA test may need to be repeated.

If the ELISA is positive or symptoms continue, a more specific test called an immunoblot test can be used to confirm Lyme disease.

The NICE Lyme Disease Quality Standard covers assessing and managing Lyme disease in people of all ages. It describes high-quality care in priority areas for improvement and is for commissioners, service providers, health and public health practitioners and
the public.

The draft quality standard is out for consultation from 12 February to 12 March
2019. The final quality standard is expected to publish in July 2019.

Professor Gillian Leng, Deputy Chief Executive and Director of Health and Social Care at NICE, said: “For most people with Lyme disease, a course of antibiotics will be effective, so it is important we diagnose and treat people as soon as possible.

“A person with Lyme disease may present with a wide range of symptoms, so we have clear advice for professionals about the use of lab tests for diagnosis and the most appropriate antibiotic treatments. If a characteristic bull’s eye rash is present, healthcare professionals should feel confident in diagnosing Lyme disease.”

Saul Faust, Professor of Paediatric Immunology and Infectious Diseases at the University of Southampton and Chair of the Guideline Committee, said: “Prompt diagnosis of Lyme disease is essential for effective management of the condition. This draft quality standard highlights key areas to help healthcare professionals and people affected by Lyme disease.

“Lab tests are necessary when a person’s symptoms are unclear, but they are not needed if a person presents the characteristic red rash, erythema migrans. Doctors should feel confident to prescribe antibiotics immediately for those with erythema migrans.”

Veronica Hughes, Chief Executive, Caudwell LymeCo Charity, said: “I hope the new quality standard will increase the number of doctors who feel confident diagnosing a Lyme disease rash on sight and treating the infection right away.

“Caudwell LymeCo Charity hears regularly from people whose doctors have diagnosed an erythema migrans but decide to check with a blood test, not realising that the rash is the more reliable of the two. Waiting for blood test results always delays treatment; when a patient has the rash, this delay is unnecessary and reduces the likelihood of total cure.”

After a diagnosis of Lyme disease, a person will receive an appropriate course of antibiotics based on their symptoms.